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KMID : 0043320150380061223
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Archives of Pharmacal Research
2015 Volume.38 No. 6 p.1223 ~ p.1231
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Antidepressant effect of Stillen™
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Jeong Hyun-Ja
Kim Jeong-Hwa
Kim Na-Rae
Yoou Myoung-Schook
Nam Sun-Young
Kim Kyu-Youb
Choi Young-Jin
Jang Jae-Bum
Kang In-Cheol
Baek Nam-In
Kim Hyung-Min
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Abstract
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Stillen™ has been used to treat patients with gastric mucosal ulcers and has an anti-inflammatory effect. It is well-known that neuro-inflammatory reactions are related to depression. Here we evaluated the antidepressant-like effect of Stillen™ on mice subjected to the forced swimming test (FST). Stillen™ and eupatilin (a major component of Stillen™) significantly decreased immobility times compared with the FST control group. In the Stillen™-administered group, increased levels of 5-hydroxytryptamine (serotonin) and brain-derived neurotrophic factor protein were observed in the hippocampus. Nissl bodies also increased in the hippocampus neuronal cytoplasm of the Stillen™-administered group. Stillen™ decreased levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (at the mRNA and protein levels) in the hippocampus and serum, compared with the control group. In addition, the mRNA expression of estrogen receptor-β increased after Stillen™ administration in the hippocampus. These findings suggest that Stillen™ should be viewed as a candidate antidepressant.
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KEYWORD
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Depression, Stillen™, Forced swimming tes, tSerotonin, Brain-derived neurotrophic factor, Estrogen receptor-β
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